Review of Human Protein Reference Database

Title: Human Protein Reference Database

URL: http://www.hprd.org/

Date Reviewed: 5/3/2006

Description: The Human Protein Reference Database has the largest online collection of literature-based human protein information. It allows users to find information such as the protein features, protein-protein interactions, post-translational modification (PTM), disease associations etc. for any given human protein.

Strengths: It generates a graph to represent the protein domains and motifs for any specific protein. This visual feature help the user to better comprehend the information. For most of the proteins, it often provides links to related research literature. The tabs feature also allow simple navigation between different features of the protein. Since the protein information are selected from the existing literature/database, so it helps summarize all the protein information in one place.

Weaknesses: Since this is like a summary of all the protein information, you can't expect to find very detailed or very specific protein information from this database (but very often, it will also provide links to the available literature for more detailed information). It only provides information strictly to human proteins and only some human-mouse interaction data.

Comprehensiveness: It is rather comprehensive.

Timeliness: They have researchers and biologists who review the literature and update the site every day.

Ease of Use: Very easy to use.

Responsiveness: It generates the search result fast.

Similar or Related Sites: UniProt

Overall Evaluation: 4 out of 5 stars because it provides integrated human protein information in a very organized lay-out.

Reviewer: TanTan Ng

Email: liza.ng@tufts.edu