DATABASE REVIEW:


TITLE:   PROTEIN KINASE RESOURCE:

URL:   http://www.sdsc.edu/kinases/pk_home.html

DATE REVIEWED:  May 8, 2000

DESCRIPTION:  Site is dedicated to Protein Kinase.

This site includeds infomation about:  1. enzymology (catalytic domains and regulatory subunits), 2. genetics, 3. molecular and structural properties of kinases. This site classifies protein kinases by their similarity in catalytic domain amino acid.

This site provides protocols for kinase assays, enzyme purification, peptide mapping, and provides a link to Life Technologies web site where other useful protein assays can be found.

This site provides links to Protein Data Bank (PDB), and structural viewing programs such as RasMol and Chime (Free software for viewing protein structure).

This site links defects in protein kinases to diseases providing links to the literature through pubmed.

This site provides links to various other sites which allow you to examine the sequence comparison (BLAST searchs), protein domains and mofits, sequence alignments, sequence presention tools, etc...

STRENGTHS:

This site provides many links to other programs which allow analysis of your particular protein kinase. Thus eliminating the need to go to each sites homepage directly.

This site provides mirror sites on their homepage to allow fast access to information.

WEAKNESSES:

This site is not very well organized. You must search extensively through this program to find all the information that is available on your protein kinase of interest.

COMPREHENSIVENESS:

This site is very out of date. I don't believe that this site has been up-dated since 1998. If you look under recent meeting on the home page they list meeting from 1998.

Most of the links have changed notices of change of web addresses. If this site was well curated, these change of addresses would be already fixed.

TIMELINESS:

This site is outdated on information on some enzymes and not on others. For instance if you look under the diseases catagorie you will find updated literature citations on Ser/Thr and Tyr PK's. They update their comprehensive list of PK Sequences monthly.
 

EASE OF USE:

This site has a nicely layed out home page to access links, but does not have a good search tool to allow one to find all of the information about their protein kinase of interest.

RESPONSIVENESS:

This site provides fast links.

SIMILAR OF RELATED SITES:
 

OVER ALL RATING:  1 = BAD    5 = EXCELLENT

I give this site a rating of 2 because it is very difficult to search for all the information known on your kinase of interest.