,
PHONE: (617) 636-0442 (office), (617) 636-6744 (lab)
FAX: (617) 636-6745
EMAIL: COCHRAN@opal.tufts.edu
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Deepa Bhavsar, Postdoctoral Fellow
Maciej Kotecki, Postdoctoral Fellow
Nick Grammatikakis, Postdoctoral Fellow
Daniel Ortiz, post-doc (Arias Lab)
Amy Simon, Clinical Fellow
Sadhana Jain, Graduate Student
Dae-Won Kim, Graduate Student
Joan Abrams, Graduate Student
Jay Lee, Graduate Student
Aliki Grammatikakis, Research Technician
E.J. Kulbakas, Research Technician
My lab is broadly interested in how growth factors such as PDGF regulate cell growth. For several years we have been working on how the c-fos promoter is regulated. We discovered a growth factor inducible called SIF which turns out to be composed of STAT family transcription factors. We also study the yeast pheromone response pathway which is remarkably analogous to some aspects of fos regulation. We have also been interested in the c-myc gene and have recently found a novel myc interacting protein using the yeast two-hybrid system. Other interests of the lab include the development of new genetic strategies for studying mammalian cells and regulation of immediate early genes in the nervous system. Click for a list of projects ongoing.
Selected Publications:
Hayes TE, Kitchen AM, Cochran BH. 1987. Inducible binding of a factor to the c-fos regulatory region. Proc. Natl. Acad. Sci. (USA) 84: 1272-1276.
Sengupta P, Cochran BH. 1991. MATalpha1 can mediate gene activation by a-mating factor. Genes and Dev. 5: 1924-1934.
Meyer, D. J., Campbell, G., Cochran, B. H., Argetsinger, L., Larner, A. C., Finbloom, D. S., Carter-Su, C. and Schwartz, J. 1993. Growth hormone induces a DNA-binding factor related to the interferon-stimulated 91-kDa transcription factor. J. Biol. Chem. 269, 4701-4704.
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