Department of Physiology, Tufts University School of Medicine

136 Harrison Ave., Boston, Massachusetts, USA

Lab and Office: Stearns Building, Room 815

Principal Investigator: Brent Cochran, Ph.D.,

Associate Professor of Physiology

PHONE: (617) 636-0442 (office), (617) 636-6744 (lab)

FAX: (617) 636-6745


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Click here to hear a message from Brent


Deepa Bhavsar, Postdoctoral Fellow

Maciej Kotecki, Postdoctoral Fellow

Nick Grammatikakis, Postdoctoral Fellow

Daniel Ortiz, post-doc (Arias Lab)

Amy Simon, Clinical Fellow

Sadhana Jain, Graduate Student

Dae-Won Kim, Graduate Student

Joan Abrams, Graduate Student

Jay Lee, Graduate Student

Aliki Grammatikakis, Research Technician

E.J. Kulbakas, Research Technician

Research Interests:

My lab is broadly interested in how growth factors such as PDGF regulate cell growth. For several years we have been working on how the c-fos promoter is regulated. We discovered a growth factor inducible called SIF which turns out to be composed of STAT family transcription factors. We also study the yeast pheromone response pathway which is remarkably analogous to some aspects of fos regulation. We have also been interested in the c-myc gene and have recently found a novel myc interacting protein using the yeast two-hybrid system. Other interests of the lab include the development of new genetic strategies for studying mammalian cells and regulation of immediate early genes in the nervous system. Click for a list of projects ongoing.

Useful Info



Unpublished Hypertext Documents (forthcoming):


Selected Publications:

Hayes TE, Kitchen AM, Cochran BH. 1987. Inducible binding of a factor to the c-fos regulatory region. Proc. Natl. Acad. Sci. (USA) 84: 1272-1276.

Sengupta P, Cochran BH. 1991. MATalpha1 can mediate gene activation by a-mating factor. Genes and Dev. 5: 1924-1934.

Meyer, D. J., Campbell, G., Cochran, B. H., Argetsinger, L., Larner, A. C., Finbloom, D. S., Carter-Su, C. and Schwartz, J. 1993. Growth hormone induces a DNA-binding factor related to the interferon-stimulated 91-kDa transcription factor. J. Biol. Chem. 269, 4701-4704.


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revised 3/16/97